• On the first day of filming, Meryl Streep told Anne Hathaway, "I think you're perfect for the role. I'm so happy we're going to be working together." Then she paused and followed it up with, "That's the last nice thing I'll say to you." And it was.

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• Meryl Streep donated her wardrobe to a charity auction.

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• Only Valentino Garavani, who had designed the black gown Meryl Streep wears in the museum benefit scene, chose to make an appearance.

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• Anna Wintour, the supposed inspiration for Miranda Priestly, reportedly really liked the film despite initial skepticism. She enjoyed Meryl Streep for her "decisive nature."

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• Anna Wintour, the powerful Vogue editor on whom Meryl Streep's character was widely believed to be based on in the novel (Lauren Weisberger once worked as her assistant), reportedly warned major fashion designers, who had been invited to make cameo appearances as themselves in the film, that they would be banished from the magazine's pages if they did so. Wintour's spokespeople deny this claim. However, it is notable that Vogue and other major women's and fashion magazines have avoided reviewing or even mentioning the book in their pages.

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• In one of the original drafts, Miranda explains how she started out as an assistant and worked her way up. It is also revealed where she grew up: Pearl River, New York. The scene then continues on to the scene of Miranda confessing her divorce to Andy. This, however, is not true to the book, as Miranda was born Miriam Princhek, to orthodox Jews, in the East End of London, and started off as an assistant to an English designer. She became well-known in London fashion, and started learning French at night to soon become Junior Editor of Chic magazine in Paris. At age 24, she changed her name to Miranda Priestly and replaced her rough, London accent with a sophisticated one, before spending ten years at French Runway before she was transferred to New York City.

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• The first bag we see Miranda carry into the office is, appropriately, a Prada bag.

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• In the scene where Miranda tells Andy she will be going to Paris instead of Emily, Andy is wearing a Chanel necklace that has Eiffel Tower charms on it.

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• The character of Miranda Priestley is supposedly based on Anna Wintour (her nickname in the industry is "Nuclear Wintour").

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• Only two days of the production took place in Paris. It was too expensive to fly Meryl Streep to Europe, so her scenes were shot in the US.

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• Meryl Streep almost left production during early stages, due to dissatisfaction with her salary.

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• Meryl Streep based her character's icily calm, quiet voice on Clint Eastwood. As for Miranda's appearance, Streep thought of the famous 85-year-old model Carmen Dell'Orefice, known for her trademark white bouffant. "I wanted a cross between her and the unassailable elegance and authority of Christine Lagarde".

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• Meryl Streep's daughter, Mamie Gummer, played a Starbucks clerk, but her scene was cut for pacing.

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• Daytime scenes in Paris, with Miranda and Andy in the back of a car. The S-class Mercedes was physically cut in half, in order to get the camera angles. It was a pre-production model that the makers could never have sold, and would have been disposed of anyway.

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• In this movie Meryl Streep plays the boss to Emily Blunt's character, in It's Complicated (2009) Streep plays the mother-in-law to John Krasinski's character, Emily Blunt's husband.

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• The idea of having Miranda appear without any make-up, in the scene where she opens up to Andrea and worries about the effect of her divorce's public disclosure on her daughters, was Meryl Streep's idea.

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• In the last scene between Miranda and Andy, Andy asks Miranda if the lifestyle that Miranda led wasn't what she wanted. Miranda responds, "Everyone wants this. Everyone wants to be us." The original line was, "Everyone wants to be me." However, Meryl Streep did not like this line, finding it too self-involved and dramatic. At the table reading of the script, Streep organically changed the line to "Everyone wants to be us." The line change stuck and was used in the film.

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• When David Frankel was talking to Stanley Tucci about how he should react when he finds out the job his character wanted is going to someone else, he told him to act like he had been nominated for an Oscar and just heard another actors name called. Meryl Streep was standing nearby and said, "Oh, I can help with that".​